Reproduction Abstracts

Context: In mammalian female germ cells, meiotic entry occurs during fetal life. The current model places retinoic acid (RA) as a key signal inducing meiotic initiation by activating the expression of stimulated by retinoic acid 8 (Stra8), a necessary factor for pre-meiotic chromosomal replication. However, the requirement of RA for meiotic initiation has been recently questioned in the female germ cells.Material and method: To clarify whether R...

Context: DMRTA2 belongs to a family of genes coding for proteins containing a DM-domain that are conserved among vertebrates and widely involved in gonadal differentiation. We recently identified Dmrta2 gene expression through transcriptome analysis performed in murine female embryonic germ cells and retrieved its expression in human fetal ovaries. The role of DMRTA2 is poorly documented and we thus conducted this study to clarify its implication in ...